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Whether through modulating central glycolytic pathways, disrupting redox homeostasis, or reshaping transcriptional programs, their functions extend well beyond the classical roles of conventional enzymes

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Any pediatric patient with the onset of a limp or complaints of hip or knee pain during INCRELEX therapy should be evaluated for slipped capital femoral epiphysis and osteonecrosis and managed accordingly

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4.4 Biological heterogeneity and value assessment Even if manufacturing and safety hurdles are overcome, the biological heterogeneity of the tumor microenvironment remains a central challenge for the clinical and economic value of TME-oriented nanoplatforms [67, 115]